Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment 8-9 August 2013
The Westin Nova Scotian
1181 Hollis Street, Halifax,
Nova Scotia, Canada
Sponsored By
Workshop Goals
The goal of this mixtures workshop is to identify and focus on key issues that present challenges in assessing the carcinogenic potential of low dose exposures to chemical mixtures in the Environment (for this workshop, "mixtures" includes combined independent exposures). This workshop will generate inputs and recommendations for the scientific community for advancing mixtures research related to carcinogenicity.
Specifically, this workshop will:
Provide participants with an update on the key areas of cancer biology that are relevant for mixtures research
Consider state-of-the-art toxicology methods and risk assessment strategies related to mixtures research and carcinogenicity
Identify and prioritize the knowledge gaps and challenges in mixtures research specific to toxicology, exposure science, and risk assessment
Obtain advice on integrating multidisciplinary capabilities to address critical topics in future mixtures research related to carcinogenicity
Provide recommendations for research on key topics
Foster collaborations between scientists
Workshop Product
Discussions from the workshop will become part of a manuscript that will be prepared for the peer-reviewed literature. This will be part of a planned special issue in Oxford’s Carcinogenesis journal, which is slated for publication in 2014. The article will capture the key issues and recommendations of workshop attendees, and describe suggestions for future directions in mixtures research.
Workshop Attendees - Summer 2013!
CLICK HERE TO SEE THE WORKSHOP VIDEOS
CLICK HERE TO HIDE THESE DETAILS
2-Day Workshop Package
2 Day workshop agenda ( shown below )
Daily shuttles between Westin hotel and NSCC Waterfront Campus
Lunch and refreshments, both days
Group dinner at the Westin Hotel (first evening)
Facility/Admin Expense
Workshop Schedule
Day 1 – 8 August, 2013
Room
Morning
Welcome, Introductions, Overview -
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (1)
Keynote Address - NIH/NIEHS - Strategic directions in Environmental Health
Rick Woychik, Deputy Director NIH/NIEHS
Video (2)
Team report - Genetic Instability
Sabine Langie, PhD, Flemish Institute For Technological Research (Belgium)
Video (3)
Team report - Sustained Proliferative Signalling
Wilhelm Engstrom, MD, Swedish University Of Agricultural Sciences (Sweden)
Video (4)
Team report - Evasion of Anti-growth Signalling
Rita Nahta, PhD, Emory University (United States)
Video (5)
Break
Team report - Resistance to Cell Death
KannanBadri Narayanan, PhD, Yeungnam University (Korea South)
Video (6)
Team report - Replicative Immortality
Amancio Carnero Moya, PhD, Institute Of Biomedicine Of Sevilla (Spain)
Video (7)
Team report - Deregulated metabolism
R. Brooks Robey, MD FASN FAHA, Dartmouth College & White River Junction VA Medical Center (United States)
Video (8)
Team report - Tumor Microenvironment
Dean Felsher, MD, PhD, Stanford University (United States)
Video (9)
Lunch
Afternoon
Team report - Angiogenesis
Zhiwei Hu MD, PhD, The Ohio State University (United States)
Video (10)
Team report - Tissue Invasion and Metastasis
Josiah Ochieng, PhD, Meharry Medical College (United States)
Video (11)
Team report - Immune System Evasion
Julia Kravchenko, MD, PhD, Duke University Medical Center (United States)
Video Video (12)
Team report - Tumor Promoting Inflammation
Patricia Thompson, PhD, The University Of Arizona Cancer Center (United States)
Video (13)
Break
EPA Toxcast, Cancer Hallmark Processes vs Carcinogenesis
Nicole C. Kleinstreuer, PhD - National Institute of Environmental Health Sciences
Video (14)
Unraveling the Health Effects of Environmental Mixtures: An NIEHS Priority
Danielle Carlin, PhD, DABT (Division of Extramural Research and Training/NIEHS)
Video (15)
A Systems Biology Approach for Assessing the Toxicity of Mixtures
Cynthia Rider, PhD, DABT (Division of National Toxicology Program/NIEHS)
EPA Toxcast, Cancer Hallmark Processes vs Carcinogenesis
Video (16)
Break
Evening
Commentary
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (17)
Low-Doses, Non-Monotonic Relationships
Laura N. Vandenberg, PhD, Tufts University (United States)
Video (18)
Considering Chemical Mixtures in Cancer Risk Assessment
Linda K. Teuschler and Glenn E. Rice, United States Environmental Protection Agency
Office of Research and Development, National Center for Environmental Assessment
Video (19)
Day 2 – 9 August, 2013
Morning
Welcome, Feedback, Overview
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (20)
Breakout Session 1 - Toxcast Data, Selectively Disruptive Chemicals
Nicole C. Kleinstreuer, PhD - National Institute of Environmental Health Sciences
Video (21a)
Breakout Session 2 - Chemical Mixtures , Toxicological Approaches and Cancer Biology
Rita Nahta, PhD, Emory University (United States)
Video (21b)
Breakout Session 3 - Chemical Mixtures, Cancer Biology, Risk Assessment Practices
Julia Kravchenko, MD, PhD, Duke University Medical Center (United States)
Video (21c)
Questions/Answers
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (21d)
Lunch
Afternoon
Breakout Session 1 - Implications and Recommendations for Future Research (knowledge gaps, modeling, testing)
Gary S Goldberg, PhD, University Of Medicine And Dentistry Of New Jersey (United States)
Video (22a)
Breakout Session 2 - Implications and Recommendations for Cancer Risk Assessment and Regulatory Decision Making
Josiah Ochieng, PhD, Meharry Medical College (United States)
Video (22b)
Breakout Session 3 - Implications and recommendations for Molecular Epidemiology
William Bisson, PhD, Oregon State University (United States)
Video (22c)
Closing Remarks
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (23)
WORKSHOP 2
A Broad-Spectrum Integrative Design for Cancer Prevention and Therapy 12-13 Aug 2013
The Westin Nova Scotian
1181 Hollis Street, Halifax,
Nova Scotia, Canada
Workshop Goals
The goal of this mixtures workshop is to leverage the rapid advances in our knowledge of the mechanics of the disease, as well as the rapidly growing body of research on natural chemicals to develop a robust and non-toxic, broad-spectrum approach to both prophylaxis and therapy (i.e., one that will be aimed at many prioritized targets simultaneously). This workshop will lay the foundation for a ground-breaking new direction in translational research that should have a much better chance of preventing disease relapse caused by intra-tumoral heterogeneity and adaptive resistance.
Specifically, this workshop will:
Provide participants with an update on the key areas of cancer biology and the most attractive therapeutic targets
Consider state-of-the-art clinical practices in integrative oncology
Identify and prioritize the knowledge gaps and challenges in research specific to targeted approaches to therapy
Lay out the foundation for a broad-spectrum approach in both prophylaxis and therapy
Provide recommendations for future research on key topics
Foster collaborations between scientists
Workshop Product
Discussions from the workshop will become part of a manuscript that will be prepared for the peer-reviewed literature. This will be part of a planned special issue in Elsevier’s Seminars in Cancer Biology journal, which is slated for publication in 2014. The article will capture the key issues and recommendations of workshop attendees, and describe suggestions for future directions in mixtures research.
Workshop Attendees - Summer 2013!
CLICK HERE TO SEE THE WORKSHOP VIDEOS
CLICK HERE TO HIDE THESE DETAILS
2-Day Workshop Package
2 Day workshop agenda (speakers shown below)
Daily shuttles between Westin hotel and NSCC Waterfront Campus
Lunch and refreshments, both days
Group dinner at the Westin Hotel (first evening)
Facility/Admin Expense
Workshop Schedule
Day 1 – 12 August, 2013
Room
Morning
Welcome, Introductions, Approach, Overview (Prophylaxis/Therapeutics)
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (24)
Integrative oncology research: Mechanistic understandings and clinical research
Jeffrey D. White, M.D., Director, Office of Cancer Complementary and Alternative Medicine, Division
of Cancer Treatment and Diagnosis, National Cancer Institute (NIH)
Video (25)
Interactive tailored clinical approaches, targeting multiple pathways: Making a difference in patient outcomes.
Keith Block, MD
Video (26)
Break
Cancer Genome Landscape (Intratumoral Heterogeneity, Therapeutic Implications, Implications for
Prevention), Bert Vogelstein, MD, Johns Hopkins University (United States)
Video (27)
Team report - Genetic Instability
Christopher Maxwell, PhD, University Of British Columbia (Canada)
Video (28)
Lunch
Afternoon
Team report - Sustained Proliferative Signalling
Mark Feitelson, PhD, Temple University (United States)
Video (29)
Team report - Evasion of Anti-growth Signalling
Dong M. Shin, MD, FACP, Emory University (United States)
Video (30)
Team report - Resistance to Cell Death
Ramzi Mohammad, Ph.D., Karmanos Cancer Institute Wayne State University (United States)
Video (31)
Team report - Replicative Immortality
Paul Yaswen, PhD, Life Sciences Division, Lawrence Berkeley National Lab (United States)
Video (32)
Break
Team report - Deregulated metabolism
Matthew Hirschey, PhD, Duke University (United States)
Video (33)
Team report - Angiogenesis
Lasse Dahl Jensen, PhD, KarolinskaInstitutet And Linkoping University (Sweden)
Video (34)
Team report - Tissue Invasion and Metastasis
Wen G Jiang, MD, PhD, Cardiff University School Of Medicine (United Kingdom)
Video (35)
Team report - Immune System Evasion
Byoung S. Kwon, PhD, National Cancer Center (Korea South)
Video (36)
Team report - Tumor Promoting Inflammation
Fredika M Robertson, PhD, The University Of Texas MD Anderson Cancer Center (United States)
Video (37)
Evening
Commentary
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (38)
Team report - Tumor Microenvironment
Nancy Boudreau, PhD, University Of California San Francisco (United States)
Video (39)
Innovative practices in Integrative Oncology
Penny Block, PhD, Block Medical center (United States)
Video (40)
Day 2 – 13 August, 2013
Morning
Welcome, Admin, Overview
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (41)
Breakout Session 1 – Phytochemicals review
Nagi B Kumar, PhD, RD, FADA, Moffitt Cancer Center (United States)
Video (42a)
Breakout Session 2 – Cancer genome (heterogeneity and the implications for target selections)
Matthew Hirschey, PhD, Duke University (United States)
Video (42b)
Breakout Session 3 – Clinical Issues: Personalizing protocols and alternate modalities to reach targeted pathways
Keith Block, MD, The Block Center for Integrative Cancer Treatment
Video (42c)
Lunch
Afternoon
Breakout Session 1 – Target selections, range of approaches, recommendations for follow-on research
Graham Pawelec, PhD, University Of Tübingen (Germany)
Video (43a)
Breakout Session 2 - Implications and recommendations for integrative oncology
Charlotte Gyllenhaal, PhD, The Block Center for Integrative Cancer Treatment
Video (43b)
Breakout Session 3 – Strategic needs (funding, resources, hurdles, barriers )
Nicol Keith, PhD, University Of Glasgow (United Kingdom)
Video (43c)
Closing Remarks
Leroy Lowe, President and Cofounder, Getting to Know Cancer
Video (44)
Workshop Facilities - Daytime Schedule
Workshop activities during the day will be held at the Nova Scotia Community College, Waterfront Campus. Participants will be picked up at the Westin Hotel each morning at 8AM and shuttled by tour bus to this facility.
This new, environmentally-friendly campus features:
modern design with open spaces
150 seat Presentation Theatre
Meeting/classroom/project rooms,
Library and computer labs
Full-service cafeteria/food court
State-of-the-art technology, including WIFI access
Daycare (please contact us in advance if you have daycare needs).
**Note that daily transportation to from the facility (from the Westin Hotel) to and lunch at the full-service cafeteria is included in the workshop package.
Workshop Facilities - Evening Schedule
At the end of the first day of each of the two-day workshops, participants will return to the Westin Halifax for a well deserved break and then the group will reconvene for dinner at the hotel. Note that additional speakers will be slated during this dinner, so all workshop participants are asked to attend (this is also included in the workshop fee).